Hospiras furosemide for injection is a sterile solution intended for intramuscular or intravenous administration. The data sheet may be written, printed or otherwise expressed, and must meet the availability, design and content requirements of whmis legislation. Furosemide is a diuretic which is an anthranilic acid derivative furosemide injection 10 mgml is a sterile, nonpyrogenic solution in vials for intravenous and intramuscular injection each ml contains. Lasix tablets for oral administration contain furosemide as the active ingredient and the following inactive ingredients. Hazards identification classification of the substance or mixture. It is a diuretic used in the treatment of congestive heart failure.
Recommended use recommended restrictions none known. Furosemide 3 not listed not listed emergency overview furosemide injection is a solution containing furosemide, a loop diuretic with a rapid onset of action. Official label printer friendly view all sections close all sections. Initially by intramuscular injection, or by slow intravenous injection, or by intravenous infusion. Hazard information carcinogen list substance iarc ntp osha furosemide 3 not listed not listed emergency overview furosemide injection is a solution containing furosemide, a loop diuretic with a rapid onset of action. This product has been classified in accordance with the hazard criteria of the cfr and the sds contains all the information required by the. Furosemide 50mg5ml solution for injection packs of 10 x 5 ml ampoules. Identification of the substancemixture and of the companyundertaking.
Buy furosemide d5 cas 54319 unlabeled, an inhibitor of cotransport in the kidney, from santa cruz. P129034 chemical family diuretic molecular weight not applicable supplier boehringer ingelheim vetmedica, inc. Lasix is a diuretic which is an anthranilic acid derivative. Furosemide is a weak carboxylic acid which exists mainly in the dissociated form in the gastrointestinal tract. Safety issues with furosemide hypertension home page. Hospira furosemide injection, usp emergency medical products. Lasix furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. What is furosemide, the diuretic substance that got. Furosemide 20mg2ml solution for injection packs of 10 x 2 ml ampoules. This emedtv page provides a list of a few common reactions to this prescription drug.
View indentification, hazards, safety information, toxicity, regulations. Furosemide tablets are a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Product and company identification product identifier pdi sanicloth af3 germicidal disposable wipe sds 010100. It helps you make more urine and to lose salt and excess water from your body.
Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patients needs. Lasix is available as white tablets for oral administration in dosage strengths of. Safety issues to discuss with your doctor are also provided, including drug interactions. Furosemide does not inhibit carbonic anhydrase and is not an aldosterone antagonist. Material safety data sheet of torsemide abmole bioscience. Sds are documents that provide critical information about hazardous chemicals. It is used in the treatment of edema associated with heart failure, including pulmonary edema, with renal and hepatic disorders, and to treat hypertension. Although most people tolerate furosemide well, side effects are possible. Heritage pharmaceuticals 23155047342 mckesson medicalsurgical. First aid measures general advice consult a physician.
Safety data sheet northwest missouri state university. Furosemide, a loop diuretic, causes hepatic necrosis in mice. Sigmaaldrich 3050 spruce street saint louis mo 63103 usa telephone. Furosemide 1% 54319 2002036 h360 repr cat 1b balance of other ingredients is less than 1% in concentration or 0. It acts to inhibit electrolyte absorption in the kidney. The metabolism and toxicity of furosemide in the wistar. Thompson et al 1999 residues in transmembrane domains i and ii determine gaminobutyric acid type aa receptor subtypeselective antagonism. Furosemide is used in the treatment of edema associated with heart failure, including pulmonary edema, with renal and hepatic disorders, and to treat hypertension. Furosemide is a prescription drug used to treat hypertension high blood pressure and edema. It has a rapid onset of action, normally within 1 hour of administration, but a relatively short duration. Figure 4 shows the uv chromatograms of furosemide and its photodegradation products at 272 nm.
Ef fect of ph on the solubility and release of furosemide from. Page 3 of 5 7 handling and storage precautions for safe handling. The metabolism and toxicity of furosemide in the wistar rat. Frusemide, lasix furosemide is a potent diruetic with rapid action. Furosemide is rapidly but incompletely absorbed 6070% on oral administration and its effect is largely over within 4 hours. Italy oel twa 5 ppm 8 mgm3 bulgaria oel twa japan oels ceilings 2 ppm 3.
This helps your body get rid of extra water and salt. Merck safety data sheets merck is providing safety data sheet sds information as a service to our customers and others seeking this information. What is furosemide, the diuretic substance that got robinson. Furosemide is a water pill diuretic that causes you to make more urine. Chemically, it is 4chloronfurfuryl5sulfamoylanthranilic acid. Not determined relevant identified uses of the substance or mixture and uses advised against intended use. Furosemide oral solution 10mgml ndc products codes. Initially 2050 mg, then by intramuscular injection or by intravenous injection or by intravenous infusion increased in steps of 20 mg every 2 hours if required, doses greater than 50 mg given by intravenous infusion only. Thus the loop diuretics reduce the reabsorption of nacl and also diminish the normal. It is used in the treatment of edema associated with heart failure, including pulmonary.
It acts to inhibit electrolyte absorption in the kidney, increasing excretion of sodium, potassium, calcium, and chloride ions, and enhancing water excretion. Furosemide 250mg25ml solution for injection packs of 10 x 25 ml ampoules. Furosemide is a chlorobenzoic acid that is 4chlorobenzoic acid substituted by a furan2ylmethylamino and a sulfamoyl group at position 2 and 5 respectively. Each ml contains furosemide 10mg and sodium chloride sufficient to render solution isotonic in water for injection. Furosemide investigated as a drug, mutagen, reproductive effector, and tumorigen. Purchase furosemide injections henry schein medical. For the treatment of edema pulmonary congestion, ascites associated with cardiac insufficiency and acute noninflammatory tissue edema in dogs. We ask that users who download significant portions of the database cite the hmdb paper in any resulting. Preparation of furosemide photodegradation products. Furosemide product number f 4381 store at room temperature product description molecular formula. Buy furosemided5 cas 54319 unlabeled, an inhibitor of cotransport in the kidney, from santa cruz. Merck is providing safety data sheet sds information as a service to our customers and others seeking this information.
Furosemide 20 mg5 ml oral solution summary of product. Per webmd, furosemide is a diuretic or a pill that causes its users to create more urine, which in turn helps rid the body of excess water and salt. Product and company identification product information product name kenalog injection 10 or 40 mgml version 2. Therapeutic uses include treatments for hypertension. Page 1 of 4 1292005 material safety data sheet product name. Pharmaceutical active details of the supplier of the safety data sheet 2. Disal furosemide tablets material safety data sheet. If inhaled if breathed in, move person into fresh air. Therefore, careful medical supervision is required and. It has a role as a xenobiotic, an environmental contaminant and a loop diuretic.
Furosemides therapeutic use and therapeutic index, its. See actual entry in rtecs for complete information. The stability of furosemide in minibags 60, 120 and 160 mg50 ml and polypropylene syringes 10, 20, 40 and 80 mg10 ml, diluted with normal saline ns, and stored at either 22 or 6c and. Mass spectra of furosemide photodegradation products. Warning lasix furosemide is a potent diuretic which, if. If you have any further questions, ask your doctor or pharmacist. Furosemide 8mgml oral solution furosemide 10mgml oral solution read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Download msds material safety data sheet of adenosine. Furosemide cas 54319 scbt santa cruz biotechnology. Identification of furosemide photodegradation products in.
To define the nature of the toxic metabolite, we examined the relationship between furosemide metabolism in cd1 mice and wistar rats. Only select registry of toxic effects of chemical substances rtecs data is presented here. Previous evidence suggested hepatotoxicity arises from metabolic bioactivation to a chemically reactive metabolite that binds to hepatic proteins. This suggests that furosemide is not ionized in water. Not classifiable as to its carcinogenicity to humans furosemide. Learn about side effects, warnings, dosage, and more. The optimal absorption site is the upper duodenum at ph 5. So called because it acts primarily by inhibiting electrolyte absorption in the loop of henle. Identification product identifier disal tablets furosemide other means of identification none. Buy furosemide cas 54319, an inhibitor of nkcc and a gaba a receptor antagonist, from santa cruz. Show this safety data sheet to the doctor in attendance.
Management of edema associated with heart failure and hepatic or renal disease. Striga is a parasitic plant called witchweed, which has been significantly reducing the amount of grains yield especially in africa. Heritage pharmaceuticals 23155047342 mckesson medical. The information contained in each sds is based on data merck believes to be correct to the best of our knowledge at the date of its publication. Furosemide acts as a noncompetitive antagonist at gaba a receptors with 100fold greater selectivity for. Capitals indicate lifethreatening, underlines indicate most frequent.