In a mixed claisen condensation or crossed claisen condensation, an ester enolate or ketone enolate is condensed with an ester that cannot form an enolate. The claisen condensation is a carboncarbon bond forming reaction that occurs between two esters or one ester and another carbonyl compound in the presence of a strong base, resulting in a. The claisen condensation between esters containing. Basepromoted claisen condensation of methyl acetate gives methyl acetoacetate, a. Mechanism, references and reaction samples of the claisen schmidt condensation. It is named after rainer ludwig claisen, who first published his work on the reaction in 1887. Check those if you need to, before working on the following problems.
This video discusses the crossed claisen ester condensation reaction mechanism and how it produces beta keto esters and carboxylic acids. Mixed crossed aldol condensation video khan academy. In the previous post, we talked about the claisen condensation reaction and went over the mechanism as well as some details regarding the importance of at least two. The claisen condensation is the ester analogue of the aldol condensation reagents.
However, if one of the ester partners has enolizable. Claisen condensation practice problems chemistry steps. The claisen condensation is a carboncarbon bond forming reaction that occurs between two. Crossed claisen ester condensation reaction mechanism youtube. In a mixed claisen condensation or crossed claisen condensation, an ester. For example, reaction of acetone a ketone which can form an enolate and. If ketones or nitriles are used as the donor in this condensation reaction, a. One full equivalent of base must be used in the claisen condensation. Formation of diethyl phenylmalonte by a crossed claisen condensation reaction. The claisen condensation is an organic reaction used to form a. We will also think about how those reactions are occurring on a molecular level with reaction mechanisms. The mixed or crossed claisen condensation, where one enolizable ester or ketone and one nonenolizable ester are used. Crossed claisen ester condensation reaction mechanism. A reaction mechanism that explains the formation of both an ester group and a carboxylic acid.